Enlarged and tender lymph glands in the neck, armpits, and groin. Benicar HCT may cause drowsiness, dizziness, or light-headedness. These effects may be worse if you take it with alcohol or certain medicines. Use Benicar HCT with caution. Drinking alcohol can increase certain side effects of this medicine.
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Benicar as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus.
What happens if I overdose Benicar? Data from one controlled trial and an epidemiologic study have suggested that high-dose olmesartan may increase cardiovascular CV risk in diabetic patients, but the overall data are not conclusive. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness; change in the amount of urine produced; chest pain; fainting; fast or irregular heartbeat; light-headedness; numbness of an arm or leg; severe or persistent dizziness; severe or persistent muscle pain or aches; shortness of breath; stiff muscles, tremors, or muscle movements that are not normal; sudden, severe headache or vomiting; sudden, unexplained weight gain; sudden vision changes; swelling of the feet, ankles, or hands; yellowing of the eyes or skin.
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. The effects of your blood pressure medicine may decrease. Your blood pressure may increase, causing headache, dizziness, or blurred vision. Your kidneys may not work as well. Also known by its generic name olmesartan medoxomil, Benicar has been associated with a host of serious side effects, including vomiting, chronic diarrhea, nausea and dramatic weight loss.
The patient must be a US citizen or legal resident. Plasma concentrations of angiotensin I and angiotensin II and plasma renin activity PRA increase after single and repeated administration of Benicar to healthy subjects and hypertensive patients. Repeated administration of up to 80 mg Benicar had minimal influence on aldosterone levels and no effect on serum potassium. In rats, olmesartan crossed the blood-brain barrier poorly, if at all. Olmesartan passed across the placental barrier in rats and was distributed to the fetus. Olmesartan was distributed to milk at low levels in rats. If vomiting, diarrhea, or excessive sweating occur, you will need to take care not to become dehydrated. This could increase your risk of low blood pressure. Contact your doctor for instructions. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Griffin JH, Hahn SM. Lisinopril-induced lithium toxicity.
In studies of ACE inhibitors in patients with unilateral or bilateral renal artery stenosis, increases in serum creatinine or blood urea nitrogen BUN have been reported. There has been no long-term use of Benicar in patients with unilateral or bilateral renal artery stenosis, but similar results may be expected. Both olmesartan medoxomil and olmesartan tested negative in the in vitro Syrian hamster embryo cell transformation assay and showed no evidence of genetic toxicity in the Ames bacterial mutagenicity test. However, both were shown to induce chromosomal aberrations in cultured cells in vitro Chinese hamster lung and tested positive for thymidine kinase mutations in the in vitro mouse lymphoma assay. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Diane Kay, COPD Patient: It basically caused me to have a transplant. If I hadn't been a smoker or worked in an environment where there is second hand smoke I probably wouldn't have had a transplant I never would have gotten as sick as I got, as quickly as I did. Gerald Staton, MD: We do see occasional patients that have various industrial exposures that can seem to contribute to that, but often they smoke cigarettes too and so it's probably a combination of factors. The most common side effect in adults was dizziness. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Severe allergic reactions rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness; change in the amount of urine produced; chest pain; dark urine; fast or irregular heartbeat; muscle pain or weakness; swelling of the hands, ankles, or feet; symptoms of low blood pressure eg, fainting, light-headedness, severe dizziness. Lab tests, including blood pressure, kidney function, and blood electrolyte levels, may be performed while you use Benicar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Contact your doctor immediately if you experience symptoms such as vision changes eg, decreased vision clearness or eye pain. The antihypertensive effect of Benicar was similar in men and women and in patients older and younger than 65 years. The effect was smaller in black patients usually a low renin population as has been seen with ACE inhibitors, beta-blockers and other angiotensin receptor blockers. Benicar had an additional blood pressure lowering effect when added to hydrochlorothiazide. Severe, chronic diarrhea with substantial weight loss has been reported in patients taking olmesartan months to years after drug initiation. Intestinal biopsies of patients often demonstrated villous atrophy. If a patient develops these symptoms during treatment with olmesartan, exclude other etiologies. Consider discontinuation of Benicar in cases where no other etiology is identified. HCT brought it down within a day. That was about a year ago. CV disease. The trial met its primary endpoint, delayed onset of microalbuminuria, but olmesartan had no beneficial effect on decline in glomerular filtration rate GFR.
Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Keep all regular medical and laboratory appointments. Tell your doctor if your condition does not improve or if it worsens for example, your blood pressure readings increase. Do not share it with other people. Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor. Benicar HCT. This has happened within months to years after Benicar HCT was started. Contact your doctor right away if you experience severe or persistent diarrhea, or sudden or unexplained weight loss. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
What do they believe to be the cause? Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Benicar is indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including the class to which this drug principally belongs. There are no controlled trials demonstrating risk reduction with Benicar. Benicar may be administered with or without food. These considerations may guide selection of therapy. Olmesartan is used to treat high blood pressure hypertension in adults and children who are at least 6 years old. It is sometimes given together with other blood pressure medications. Keep all away from children and pets. Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 20 mg once a day. If the child cannot swallow the tablets, an oral suspension is recommended. Use is not recommended. Ask your healthcare professional how you should dispose of any medicine you do not use.
Increases in serum lithium concentrations and lithium toxicity have been reported during concomitant administration of lithium with angiotensin II receptor antagonists, including Benicar. Monitor serum lithium levels during concomitant use. The antihypertensive effect of Benicar was smaller in black patients usually a low renin population as has been seen with ACE inhibitors, beta-blockers and other angiotensin receptor blockers. The antihypertensive effects of Benicar in the pediatric population were evaluated in a randomized, double-blind study involving 302 hypertensive patients aged 6 to 16 years. The study population consisted of an all black cohort of 112 patients and a mixed racial cohort of 190 patients, including 38 blacks. The etiology of the hypertension was predominantly essential hypertension 87% of the black cohort and 67% of the mixed cohort. Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics water pills. Follow your doctor's instructions about the type and amount of liquids you should drink while taking olmesartan. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. All of the participants were women, so Lin can't say for sure that the association holds for men, although she says there is ''no biological reason to think it wouldn't. When they looked at the diet information, they found that the 30% decline in kidney function was associated with drinking two or more artificially sweetened sodas a day.
Diuretics during lithium therapy. Gerald Staton, MD: Asthma seems to be a predisposition that if you are an asthmatic as a child and then smoke cigarettes then you have a fairly significantly higher risk of developing COPD later in life. Laboratory Test Findings: In controlled clinical trials, clinically important changes in standard laboratory parameters were rarely associated with administration of Benicar. This information should not be used to decide whether or not to take Benicar or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Benicar. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Benicar. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Benicar. HRCT scan high resolution CT to provide an even more detailed look at the lungs and lymph nodes than provided by a chest X-ray. Solomon JG. Lithium toxicity precipitated by a diuretic. The antihypertensive effect of angiotensin II receptor antagonists, including olmesartan medoxomil may be attenuated by NSAIDs including selective COX-2 inhibitors. ARBs with new-onset diabetes mellitus. No significant drug interactions were reported in studies in which Benicar was co-administered with digoxin or warfarin in healthy volunteers. An AT 2 receptor is found also in many tissues, but this receptor is not known to be associated with cardiovascular homeostasis. Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 40 mg once a day. If the child cannot swallow the tablets, an oral suspension is recommended. Keep out of the reach of children. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Diane Kay, COPD Patient: It took me forever to walk up the driveway from getting the mail. I had to take breaks, and you just think you getting older and at that the time I was a smoker. so you think you know you're older and you smoking and you know. What do you expect? This experience included about 900 patients treated for at least 6 months and more than 525 for at least 1 year. Treatment with Benicar was well tolerated, with an incidence of adverse reactions similar to placebo. Events generally were mild, transient and had no relationship to the dose of Benicar. Check the label on the medicine for exact dosing instructions.
The renin-angiotensin aldosterone system RAAS plays a critical role in kidney development. RAAS blockade has been shown to lead to abnormal kidney development in very young mice. Administering drugs that act directly on the renin- angiotensin aldosterone system RAAS can alter normal renal development. Put another way: the women who drank two or more diet sodas a day had a decline in their glomerular filtration rate, a measure of kidney function, of 3 milliliters per minute per year. The information contained in the Truven Health Micromedex products as delivered by Drugs. Do not stop taking any medications without consulting your healthcare provider. This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Narrator: That's true for about 85-percent of COPD cases. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. SQ 14225, in low renin hypertension. Possibly Safe: NOT RECOMMENDED IN PRE-ECLAMPSIA AND OTHER PREGNANCY-INDUCED HYPERTENSION. Precaution: LIMITED AMOUNTS EXCRETED WITH NO KNOWN ADVERSE EFFECTS IN INFANT. Patients with renal insufficiency have elevated serum concentrations of olmesartan compared to subjects with normal renal function. The volume of distribution of olmesartan is approximately 17 L. Olmesartan is highly bound to plasma proteins 99% and does not penetrate red blood cells. The protein binding is constant at plasma olmesartan concentrations well above the range achieved with recommended doses.
Angiotensin II type 1 receptor blockers ARBs are commonly used in the treatment of hypertension high blood pressure and heart failure. Benicar, manufactured by Daiichi Sankyo, is one of the more widely prescribed ARBs since its FDA approval in 2002. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. The overall frequency of adverse reactions was not dose-related. Analysis of gender, age and race groups demonstrated no differences between Benicar and placebo-treated patients. Store Benicar between 68 and 77 degrees F 20 and 25 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Benicar out of the reach of children and away from pets. Check with your doctor for instructions. This service is not currently available in Montana. Narrator: For WebMD, I'm Rhonda Rowland. No proof of income is required. Check the website for the exact price. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Concomitant administration of 40 mg olmesartan medoxomil and 3750 mg colesevelam hydrochloride in healthy subjects resulted in 28% reduction in Cmax and 39% reduction in AUC of olmesartan.
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Overdose symptoms may include extreme dizziness, fast or slow heartbeat, or fainting. Facial edema was reported in five patients receiving Benicar. Angioedema has been reported with angiotensin II antagonists. Kumahara Y. Hormonal responses to long-term converting enzyme inhibition in hypertensive patients. Benicar was generally well tolerated in pediatric patients, and the adverse experience profile was similar to that described for adults.
Middleton B, Bates DW. Drug-drug interactions that should be non-interruptive in order to reduce alert fatigue in electronic health records. Lab tests, including kidney function, blood pressure, and blood electrolytes, may be performed while you use Benicar HCT. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Your doctor may occasionally change your dose to make sure you get the best results. The patient must also be a US resident. Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function including acute renal failure compared to monotherapy. Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy. In general, avoid combined use of RAS inhibitors. Closely monitor blood pressure, renal function and electrolytes in patients on Benicar and other agents that affect the RAS.
This medication works very well with no side effects. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. Benicar may not work as well in black patients. Discuss any questions or concerns with your doctor.
Serious. These medicines may interact and cause very harmful effects. You may also need to avoid taking hydrochlorothiazide and olmesartan with aliskiren if you have kidney disease. In patients who are elderly, volume-depleted including those on diuretic therapy or with compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including olmesartan medoxomil, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving olmesartan medoxomil and NSAID therapy.